Brain mechanisms underlying sleep complaints in health and neuropsychiatry
|Date||13 October 2015|
|Time||16:00 - 18:00|
Insomnia is the most common health complaint and has serious consequences. Our understanding of underlying brain mechanisms is limited. We hypothesized that the lack of robust findings may be due to heterogeneity of underlying causes of insomnia, that are not necessarily limited to different parts of the sleep regulating systems. The presentation will first illustrate different sleep-regulating circuits that can be involved. Second, it will be shown that a data-driven clustering approach to a large database of multivariate psychometric profiles assessed in volunteers of www.sleepregistry.org suggests different subtypes of insomnia. Interestingly, subtypes differentiated hardly on sleep constructs. Third, it will be shown that the use of MRI tools in careful selections of homogeneous sets of participants can reveal neural correlates of sound sleep and insomnia severity. Notably, these correlates can be different depending on psychiatric phenotype, and include circuits involved in reward processing and in fast synchronization of distant brain areas.
Further reading: Altena et al., Biol Psychiatry 2010;67:182; Piantoni et al., J Neurosci 2013;33:227; Stoffers et al., Front Neurol 2012;3:105; Stoffers et al., Brain 2014;137:610; Van Der Werf et al., Biol Psychiatry 2010;68:950