The Haber lab focuses on the neural network that underlies incentive learning and decision-making that leads to the development of action plans.
The cortico-cortical and cortico-basal ganglia networks are central to incentive-based learning and good decision making. There is growing consensus that obsessive-compulsive disorder, major depressive disorder, and addiction are manifestations of dysfunction of these networks. Behavioral responses to environmental cues depend not only on the ability to evaluate different aspects of reward, but also the ability to inhibit inappropriate choices.
Integrating reward information with that involved in cognition and motor control is thus essential for developing motivational control and appropriately adaptive behaviors. Human imaging studies have characterized large scale distributed networks and the location of ‘hubs’, regions that are central for integrating and distributing information. The fibers that connect these structures, both within and between networks, are central targets for invasive and noninvasive therapeutic approaches in psychiatric illnesses.
The first part of this talk will combine the precision of anatomy in nonhuman primates (NHPs) with high resolution imaging in both NHPs and humans to localize and characterize key hub locations within the cortex and striatum.
The second part of the talk will demonstrate the position and organization of specific cortical fibers through the internal capsule, subthalamic nucleus, and subgenual white matter, three deep brain stimulation targets for depression and obsessive-compulsive disorder.