Dr. J.M. (Anneke) Alkemade
Faculty of Social and Behavioural Sciences
Programme group Brain and Cognition
Visiting address
- Nieuwe Achtergracht 129
Postal address
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Postbus 15915
1001 NK Amsterdam
Contact details
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Profile
My research efforts are focused on the functional anatomy of subcortical brain structures involved complex psychological processes including decision-making. The work is focused on the integration of microscopy approaches with 7 Tesla magnetic resonance imaging (MRI) of the brain.
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Publications
2023
Alkemade, A., Großmann, R., Bazin, P.-L., & Forstmann, B. U. (2023). Mixed methodology in human brain research: integrating MRI and histology. Brain Structure and Function, 228(6), 1399-1410. https://doi.org/10.1007/s00429-023-02675-2 [details]- Isherwood, S. J. S., Bazin, P., Miletić, S., Stevenson, N. R., Trutti, A. C., Tse, D. H. Y., Heathcote, A., Matzke, D., Innes, R. J., Habli, S., Sokołowski, D. R., Alkemade, A., Håberg, A. K., & Forstmann, B. U. (2023). Investigating Intra-Individual Networks of Response Inhibition and Interference Resolution using 7T MRI. NeuroImage, 271, Article 119988. https://doi.org/10.1016/j.neuroimage.2023.119988 [details]
2022
- Alkemade, A., Bazin, P.-L., Balesar, R., Pine, K., Kirilina, E., Möller, H. E., Trampel, R., Kros, J. M., Keuken, M. C., Bleys, R. L. A. W., Swaab, D. F., Herrler, A., Weiskopf, N., & Forstmann, B. U. (2022). A unified 3D map of microscopic architecture and MRI of the human brain. Science Advances, 8(17), Article eabj7892. https://doi.org/10.1126/sciadv.abj7892 [details]
- Alkemade, A., Mulder, M. J., Trutti, A. C., & Forstmann, B. U. (2022). Manual delineation approaches for direct imaging of the subcortex. Brain Structure and Function, 227(1), 219-297. https://doi.org/10.1007/s00429-021-02400-x [details]
- Brammerloh, M., Kirilina, E., Alkemade, A., Bazin, P-L., Jantzen, C., Jäger, C., Herrler, A., Pine, K. J., Gowland, P. A., Morawski, M., Forstmann, B. U., & Weiskopf, N. (2022). Swallow Tail Sign: Revisited. Radiology, 305(3), 674–677. Advance online publication. https://doi.org/10.1148/radiol.212696 [details]
- Keuken, M. C., Liebrand, L. C., Bazin, P.-L., Alkemade, A., van Berendonk, N., Groot, J. M., Isherwood, S. J. S., Kemp, S., Lute, N., Mulder, M. J., Trutti, A. C., Caan, M. W. A., & Forstmann, B. U. (2022). A high-resolution multi-shell 3T diffusion magnetic resonance imaging dataset as part of the Amsterdam Ultra-high field adult lifespan database (AHEAD). Data in Brief, 42, Article 108086. https://doi.org/10.1016/j.dib.2022.108086 [details]
- Miletić, S., Bazin, P. L., Isherwood, S. J. S., Keuken, M. C., Alkemade, A., & Forstmann, B. U. (2022). Charting human subcortical maturation across the adult lifespan with in vivo 7 T MRI. NeuroImage, 249, Article 118872. https://doi.org/10.1016/j.neuroimage.2022.118872 [details]
2021
- Alkemade, A., & Forstmann, B. U. (2021). Imaging of the human subthalamic nucleus. In D. F. Swaab, F. Kreier, P. J. Lucassen, A. Salehi, & R. M. Buijs (Eds.), The Human Hypothalamus: Middle and Posterior Region (pp. 403-416). (Handbook of Clinical Neurology; Vol. 180). Elsevier. https://doi.org/10.1016/B978-0-12-820107-7.00025-2 [details]
- Brammerloh, M., Morawski, M., Friedrich, I., Reinert, T., Lange, C., Pelicon, P., Vavpetič, P., Jankuhn, S., Jäger, C., Alkemade, A., Balesar, R., Pine, K., Gavriilidis, F., Trampel, R., Reimer, E., Arendt, T., Weiskopf, N., & Kirilina, E. (2021). Measuring the iron content of dopaminergic neurons in substantia nigra with MRI relaxometry. NeuroImage, 239, Article 118255. Advance online publication. https://doi.org/10.1016/j.neuroimage.2021.118255 [details]
- Isherwood, S. J. S., Bazin, P.-L., Alkemade, A., & Forstmann, B. U. (2021). Quantity and quality: Normative open-access neuroimaging databases. PLoS ONE, 16(3), Article e0248341. https://doi.org/10.1371/journal.pone.0248341 [details]
- Keuken, M. C., Alkemade, A., Stevenson, N., Innes, R. J., & Forstmann, B. U. (2021). Structure-function similarities in deep brain stimulation targets cross-species. Neuroscience and Biobehavioral Reviews, 131, 1127-1135. https://doi.org/10.1016/j.neubiorev.2021.10.029 [details]
2020
- Alkemade, A., Mulder, M. J., Groot, J. M., Isaacs, B. R., van Berendonk, N., Lute, N., Isherwood, S. J. S., Bazin, P.-L., & Forstmann, B. U. (2020). The Amsterdam Ultra-high field adult lifespan database (AHEAD): A freely available multimodal 7 Tesla submillimeter magnetic resonance imaging database. NeuroImage, 221, Article 117200. https://doi.org/10.1016/j.neuroimage.2020.117200 [details]
- Alkemade, A., Pine, K., Kirilina, E., Keuken, M. C., Mulder, M. J., Balesar, R., Groot, J. M., Bleys, R. L. A. W., Trampel, R., Weiskopf, N., Herrler, A., Möller, H. E., Bazin, P.-L., & Forstmann, B. U. (2020). 7 Tesla MRI Followed by Histological 3D Reconstructions in Whole-Brain Specimens. Frontiers in Neuroanatomy, 14, Article 536838. https://doi.org/10.3389/fnana.2020.536838 [details]
- Bazin, P-L., Nijsse, H. E., van der Zwaag, W., Gallichan, D., Alkemade, A., Vos, F. M., Forstmann, B. U., & Caan, M. W. A. (2020). Sharpness in motion corrected quantitative imaging at 7T. NeuroImage, 222, Article 117227. https://doi.org/10.1016/j.neuroimage.2020.117227 [details]
- Bazin, P.-L., Alkemade, A., Mulder, M. J., Henry, A. G., & Forstmann, B. U. (2020). Multi-contrast anatomical subcortical structures parcellation. eLife, 9, Article e59430. https://doi.org/10.7554/eLife.59430 [details]
- Isaacs, B. R., Keuken, M. C., Alkemade, A., Temel, Y., Bazin, P. L., & Forstmann, B. U. (2020). Methodological Considerations for Neuroimaging in Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease Patients. Journal of Clinical Medicine, 9(10), Article 3124. https://doi.org/10.3390/jcm9103124 [details]
- Isaacs, B. R., Mulder, M. J., Groot, J. M., van Berendonk, N., Lute, N., Bazin, P.-L., Forstmann, B. U., & Alkemade, A. (2020). 3 versus 7 Tesla magnetic resonance imaging for parcellations of subcortical brain structures in clinical settings. PLoS ONE, 15(11), Article e0236208. https://doi.org/10.1371/journal.pone.0236208 [details]
- van Wijk, B. C. M., Alkemade, A., & Forstmann, B. U. (2020). Functional segregation and integration within the human subthalamic nucleus from a micro- and meso-level perspective. Cortex, 131, 103-113. https://doi.org/10.1016/j.cortex.2020.07.004 [details]
2019
- Alkemade, A., de Hollander, G., Miletic, S., Keuken, M. C., Balesar, R., de Boer, O., Swaab, D. F., & Forstmann, B. U. (2019). The functional microscopic neuroanatomy of the human subthalamic nucleus. Brain Structure and Function, 224(9), 3212-3227. https://doi.org/10.1007/s00429-019-01960-3 [details]
- Bazin, P.-L., Alkemade, A., van der Zwaag, W., Caan, M., Mulder, M., & Forstmann, B. U. (2019). Denoising High-Field Multi-Dimensional MRI With Local Complex PCA. Frontiers in Neuroscience, 13, Article 1066. https://doi.org/10.3389/fnins.2019.01066 [details]
- Mulder, M. J., Keuken, M. C., Bazin, P.-L., Alkemade, A., & Forstmann, B. U. (2019). Size and shape matter: The impact of voxel geometry on the identification of small nuclei. PLoS ONE, 14(4), Article e0215382. https://doi.org/10.1371/journal.pone.0215382 [details]
2018
- Alkemade, A., Groot, J. M., & Forstmann, B. U. (2018). Do We Need a Human post mortem Whole-Brain Anatomical Ground Truth in in vivo Magnetic Resonance Imaging? Frontiers in Neuroanatomy, 12, Article 110. https://doi.org/10.3389/fnana.2018.00110 [details]
2017
- Alkemade, A., de Hollander, G., Keuken, M. C., Schäfer, A., Ott, D. V. M., Schwarz, J., Weise, D., Kotz, S. A., & Forstmann, B. U. (2017). Comparison of T2∗-weighted and QSM contrasts in Parkinson's disease to visualize the STN with MRI. PLoS ONE, 12(4), Article e0176130. https://doi.org/10.1371/journal.pone.0176130 [details]
- Forstmann, B. U., & Alkemade, A. (2017). The Neuroanatomy and Neurochemistry of Response Inhibition. In T. Egner (Ed.), The Wiley Handbook of Cognitive Control (pp. 274-291). Wiley Blackwell. https://doi.org/10.1002/9781118920497.ch16 [details]
- Forstmann, B. U., de Hollander, G., van Maanen, L., Alkemade, A., & Keuken, M. C. (2017). Towards a mechanistic understanding of the human subcortex. Nature Reviews Neuroscience, 18(1), 57-65. Advance online publication. https://doi.org/10.1038/nrn.2016.163 [details]
2016
- ten Kulve, J. S., van Bloemendaal, L., Balesar, R., IJzerman, R. G., Swaab, D. F., Diamant, M., la Fleur, S. E., & Alkemade, A. (2016). Decreased Hypothalamic Glucagon-Like Peptide-1 Receptor Expression in Type 2 Diabetes Patients. Journal of clinical endocrinology and metabolism, 101(5), 2122-2129. https://doi.org/10.1210/jc.2015-3291 [details]
2015
- Alkemade, A. (2015). Thyroid hormone and the developing hypothalamus. Frontiers in Neuroanatomy, 9, Article 15. https://doi.org/10.3389/fnana.2015.00015 [details]
- Alkemade, A., Schnitzler, A., & Forstmann, B. U. (2015). Topographic organization of the human and non-human primate subthalamic nucleus. Brain Structure and Function, 220(6), 3075-3086. https://doi.org/10.1007/s00429-015-1047-2 [details]
- Boonstra, E., de Kleijn, R., Colzato, L. S., Alkemade, A., Forstmann, B. U., & Nieuwenhuis, S. (2015). Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Frontiers in Psychology, 6, Article 1520. https://doi.org/10.3389/fpsyg.2015.01520 [details]
- Forstmann, B. U., Keuken, M. C., & Alkemade, A. (2015). An introduction to human brain anatomy. In B. U. Forstmann, & E-J. Wagenmakers (Eds.), An introduction to model-based cognitive neuroscience (pp. 71-89). Springer. https://doi.org/10.1007/978-1-4939-2236-9_4 [details]
- Weiss, M., Alkemade, A., Keuken, M. C., Müller-Axt, C., Geyer, S., Turner, R., & Forstmann, B. U. (2015). Spatial normalization of ultrahigh resolution 7 T magnetic resonance imaging data of the postmortem human subthalamic nucleus: a multistage approach. Brain Structure and Function, 220(3), 1695-1703. Advance online publication. https://doi.org/10.1007/s00429-014-0754-4 [details]
2014
- Alkemade, A., & Forstmann, B. U. (2014). Do we need to revise the tripartite subdivision hypothesis of the human subthalamic nucleus (STN)? NeuroImage, 95, 326-329. https://doi.org/10.1016/j.neuroimage.2014.03.010 [details]
- Borgers, A. J., Koopman, K. E., Bisschop, P. H., Serlie, M. J., Swaab, D. F., Fliers, E., la Fleur, S. E., & Alkemade, A. (2014). Decreased serotonin transporter immunoreactivity in the human hypothalamic infundibular nucleus of overweight subjects. Frontiers in Neuroscience, 8, Article 106. https://doi.org/10.3389/fnins.2014.00106 [details]
- Borgers, A. J., van den Born, B-JH., Alkemade, A., Eeftinck Schattenkerk, D. W., van Lieshout, J. J., Wesseling, K. H., Bisschop, P. H., & Westerhof, B. E. (2014). Determinants of vascular and cardiac baroreflex sensitivity values in a random population sample. Medical & Biological Engineering & Computing, 52(1), 65-73. Advance online publication. https://doi.org/10.1007/s11517-013-1111-0 [details]
- Forstmann, B. U., Keuken, M. C., Schafer, A., Bazin, P-L., Alkemade, A., & Turner, R. (2014). Multi-modal ultra-high resolution structural 7-Tesla MRI data repository. Scientific Data, 1, Article 140050. https://doi.org/10.1038/sdata.2014.50 [details]
- Girault, E. M., Guigas, B., Alkemade, A., Foppen, E., Ackermans, M. T., la Fleur, S. E., Fliers, E., & Kalsbeek, A. (2014). Chronic treatment with olanzapine increases adiposity by changing fuel substrate and causes desensitization of the acute metabolic side effects. Naunyn-Schmiedeberg's Archives of Pharmacology, 387(2), 185-195. https://doi.org/10.1007/s00210-013-0933-5 [details]
2013
- Alkemade, A. (2013). Subdivisions and anatomical borders of the subthalamic nucleus. The Journal of Neuroscience, 33(22), 9233-9234. https://doi.org/10.1523/JNEUROSCI.1266-13.2013 [details]
- Alkemade, A., Keuken, M. C., & Forstmann, B. U. (2013). A perspective on terra incognita: uncovering the neuroanatomy of the human subcortex. Frontiers in Neuroanatomy, 7, Article 40. https://doi.org/10.3389/fnana.2013.00040 [details]
- Borgers, A. J., Alkemade, A., van de Giessen, E. M., Drent, M. L., Booij, J., Bisschop, P. H., & Fliers, E. (2013). Imaging of serotonin transporters with [123I]FP-CIT SPECT in the human hypothalamus. EJNMMI Research, 3, 34. Article 34. https://doi.org/10.1186/2191-219X-1-34 [details]
- Borgers, A. J., Fliers, E., Siljee, J. E., Swaab, D. F., Van Someren, E. J. W., Bisschop, P. H., & Alkemade, A. (2013). Arginine vasopressin immunoreactivity is decreased in the hypothalamic suprachiasmatic nucleus of subjects with suprasellar tumors. Brain Pathology, 23(4), 440-444. https://doi.org/10.1111/bpa.12016 [details]
- Mittag, J., Lyons, D. J., Sällström, J., Vujoviv, M., Dudazy-Gralla, S., Warner, A., Wallis, K., Alkemade, A., Nordström, K., Monyer, H., Broberger, C., Arner, A., & Vennström, B. (2013). Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions. The journal of clinical investigation, 123(1), 509-516. https://doi.org/10.1172/JCI65252 [details]
- Siljee, J. E., Unmehopa, U. A., Kalsbeek, A., Swaab, D. F., Fliers, E., & Alkemade, A. (2013). Melanocortin 4 receptor distribution in the human hypothalamus. European journal of endocrinology, 168(3), 361-369. https://doi.org/10.1530/EJE-12-0750 [details]
2005
- Alkemade, A., Ummehopa, U. A., Wiersinga, W. M., Swaab, D. F., & Fliers, E. (2005). Glucocorticoids decrease thyrotropin-releasing hormone messenger ribonucleic acid expression in the paraventricular nucleus of the human hypothalamus. Journal of clinical endocrinology and metabolism, 90(1), 323-327. https://doi.org/10.1210/jc.2004-1430 [details]
2016
- Forstmann, B. U., Keuken, M. C., & Alkemade, A. (2016). The next step for imaging the subthalamic nucleus. Brain, 139(12), Article e69. https://doi.org/10.1093/brain/aww245 [details]
2005
- Alkemade, J. M. (2005). Central components of the human hypothalamus-pituitary-thyroid axis and their role in nonthyroidal illness. [Thesis, fully internal, Universiteit van Amsterdam]. [details]
2023
- Bazin, P. L. E. A., Forstmann, B. U., Alkemade, J. M., Miletić, S. & Isherwood, S. J. S. (8-7-2023). AHEAD quantitative MRI templates (MNI2009b). Universiteit van Amsterdam. https://doi.org/10.21942/uva.19646364.v3
- Isherwood, S., Bazin, P., Miletić, S., Stevenson, N., Trutti, A., H. Y. Tse, D., Heathcote, A., Matzke, D., Habli, S., Sokołowski, D. R., Alkemade, A., Håberg, A., Forstmann, B. & Innes, R. (8-6-2023). Investigating Intra-Individual Networks of Response Inhibition and Interference Resolution using 7T MRI data. Universiteit van Amsterdam. https://doi.org/10.21942/uva.22240393.v1
2022
- Bazin, P. L. E. A., Forstmann, B. U. & Alkemade, A. (14-6-2022). Ahead brain 122017 - 3D reconstructions. Universiteit van Amsterdam. https://doi.org/10.21942/uva.16834114.v2
- Bazin, P. L. E. A., Forstmann, B. U. & Alkemade, A. (14-6-2022). Ahead Brain 152017 - 3D reconstructions. Universiteit van Amsterdam. https://doi.org/10.21942/uva.14260064.v2
- Bazin, P. L. E. A., Forstmann, B. U. & Alkemade, A. (14-6-2022). Ahead Brain 152017 - Automated parcellations. Universiteit van Amsterdam. https://doi.org/10.21942/uva.14260079.v2
- Alkemade, J. M., Mulder, M., Groot, J., Isaacs, B., van Berendonk, N., Lute, N., Isherwood, S. J. S., Bazin, P. L. E. A. & Forstmann, B. U. (3-6-2022). The Amsterdam Ultra-high field adult lifespan database (AHEAD): A freely available multimodal 7 Tesla submillimeter magnetic resonance imaging database. Universiteit van Amsterdam. https://doi.org/10.21942/uva.10007840.v2
- Bazin, P. L. E. A., Forstmann, B. U., Alkemade, J. M., Miletić, S. & Isherwood, S. J. S. (9-5-2022). MASSP 2021 Middle-aged Probabilistic Atlas. Universiteit van Amsterdam. https://doi.org/10.21942/uva.19646334.v1
- Bazin, P. L. E. A., Forstmann, B. U., Alkemade, J. M., Miletić, S. & Isherwood, S. J. S. (9-5-2022). MASSP 2021 Younger Probabilistic Atlas. Universiteit van Amsterdam. https://doi.org/10.21942/uva.19646328.v1
- Bazin, P. L. E. A., Forstmann, B. U., Alkemade, J. M., Miletić, S. & Isherwood, S. J. S. (9-5-2022). MASSP 2021 Older Probabilistic Atlas. Universiteit van Amsterdam. https://doi.org/10.21942/uva.19646346.v1
- Bazin, P. L. E. A., Forstmann, B. U., Alkemade, J. M., Miletić, S. & Isherwood, S. J. S. (9-5-2022). MASSP 2021 Lifespan Probabilistic Atlas. Universiteit van Amsterdam. https://doi.org/10.21942/uva.19646313.v1
- Bazin, P. L. E. A., Forstmann, B. U. & Alkemade, A. (4-3-2022). Ahead Brain 122017 - MNI coregistrations. Universiteit van Amsterdam. https://doi.org/10.21942/uva.16834186.v1
- Bazin, P. L. E. A., Forstmann, B. U. & Alkemade, A. (4-3-2022). Ahead Brain 152017 - Original stains. Universiteit van Amsterdam. https://doi.org/10.21942/uva.16843039.v1
- Bazin, P. L. E. A., Forstmann, B. U. & Alkemade, A. (4-3-2022). Ahead Brain 122017 - Automated parcellations. Universiteit van Amsterdam. https://doi.org/10.21942/uva.16834159.v1
- Bazin, P. L. E. A., Forstmann, B. U. & Alkemade, A. (4-3-2022). Ahead Brain 122017 - Original stains. Universiteit van Amsterdam. https://doi.org/10.21942/uva.16844500.v1
- Bazin, P. L. E. A., Forstmann, B. U. & Alkemade, A. (4-3-2022). Ahead brain 152017 - MNI coregistrations. Universiteit van Amsterdam. https://doi.org/10.21942/uva.14260088.v1
- Bazin, P. L. E. A., Forstmann, B. & Alkemade, A. (2022). Ahead Brain 152017 - Automated parcellations. Universiteit van Amsterdam. https://doi.org/10.21942/uva.14260079.v1
- Bazin, P. L. E. A., Forstmann, B., Alkemade, A., Miletić, S. & Isherwood, S. (2022). AHEAD quantitative MRI templates (MNI2009b). Universiteit van Amsterdam. https://doi.org/10.21942/uva.19646364.v1
2021
- Keuken, M., Liebrand, L., Bazin, P., Alkemade, A., van Berendonk, N., Groot, J., Isherwood, S., Kemp, S., Lute, N., Mulder, M., Trutti, A., Caan, M. W. A. & Forstmann, B. (28-10-2021). A high-resolution multi-shell 3T diffusion magnetic resonance imaging dataset as part of the Amsterdam Ultra-high field adult lifespan database (AHEAD) - dataset. Universiteit van Amsterdam. https://doi.org/10.21942/uva.16884703.v1
- Alkemade, J. M., Mulder, M. J., Trutti, A. C. & Forstmann, B. U. (16-3-2021). Manual Delineation approaches for direct imaging of the subcortex. Universiteit van Amsterdam. https://doi.org/10.21942/uva.14216504.v2
- Forstmann, B., Keuken, M., Schafer, A., Bazin, P.-L., Alkemade, A. & Turner, R. (2021). Data from: Multi-modal ultra-high resolution structural 7-Tesla MRI data repository. DRYAD. https://doi.org/10.5061/dryad.fb41s
2020
- Alkemade, J. M., Pine, K., Kirilina, E., Keuken, M., Mulder, M., Balesar, R., Groot, J., L. A. W. Bleys, R., Trampel, R., Weiskopf, N., Herrler, A., Möller, H., Bazin, P. & Forstmann, B. (14-9-2020). 7 Tesla MRI followed by histological 3D reconstructions in whole-brain specimens. Universiteit van Amsterdam. https://doi.org/10.21942/uva.12496853.v1
- Bazin, P. L. E. A., Forstmann, B. & Alkemade, A. (14-5-2020). AHEAD template. Universiteit van Amsterdam. https://doi.org/10.21942/uva.12301106.v2
2019
- Bazin, P. L. E. A., Alkemade, A., van der Zwaag, W., Caan, M. W. A., Mulder, M. & Forstmann, B. (5-4-2019). Raw measurements for the statistics. Universiteit van Amsterdam. https://doi.org/10.21942/uva.7952270.v1
2018
- Alkemade, A., Kotz, S. A., Ott, D. V. M., Keuken, M. C., Schwarz, J., Weise, D., Schäfer, A., Forstmann, B. U. & de Hollander, G. (2018). Data from: Comparison of T2*-weighted and QSM contrasts in Parkinson's disease to visualize the STN with MRI. DRYAD. https://doi.org/10.5061/dryad.t7kp7
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Alkemade, A., Großmann, R., Bazin, P.-L., & Forstmann, B. U. (2023). Mixed methodology in human brain research: integrating MRI and histology. Brain Structure and Function, 228(6), 1399-1410.